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Nitric oxide activates guanylate cyclase and increases guanosine 3:5-cyclic monophosphate levels in various tissue preparations

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These reactive aldehydes can attack additional intracellular targets, including proteins and DNA, extending initial membrane damage to other macromolecules and cellular regions

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Oxidative damage to cells is one of the leading components of both the visual signs of aging as well as aging processes like senescence (cellular/tissue aging), hormonal aging, metabolic aging, and DNA damage that led to both disease and dysfunction

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