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Although the majority of HFS are idiopathic, presumably due to irritation or compression of the facial nerve by an aberrant blood vessel in the middle or posterior fossa or other vascular condition (e.g., arteritis), there are other causes of facial nerve compression, including tumors [ 19 , 23 ]

Increasing the concentration of active metabolites at the tumor site, will subsequently limit the concentration of active drug at other sites, reducing side effects

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