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The preservation of nicotinamide substrate drastically increases the efficiency of the NAD+ salvage pathway

Confirming or excluding interference Discordance between the result and the clinical picture raises the possibility of assay interference

This depends on how severe the deficiency is and how well the patient responds to treatment

Therefore, in patients with significantly impaired renal function or in infants, the therapy should be used only if clearly indicated and with careful monitoring

Alternatively, the pain may be distributed in a more widespread manner

This study used the NNMTi 5-amino-1-methylquinolinium (5A-M1Q), since our lab has set precedence using this probe molecule for proof-of-concept studies 8