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in fibromyalgia, this could be typical low-level sensory input, such as touch or movement, which result in widespread areas of pain

pmid:6790531 38

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However, when superimposing the membrane-bound mTORC1RHEB structure with the soluble mTORC1RHEB structure on the basis of the mTOR subunit, we observed a conformational change in the RAPTOR subunit, with a rotation of about 7 towards the HEAT domain of mTOR (Extended Data Fig

13 C-NMR (100 MHz, CDCl 3 ) ppm = 171.2, 159.4, 149.7, 142.5, 133.4, 123.6, 123.4, 119.3, 118.5, 113.9, 110.9, 109.1, 50.9, 46.6, 21.9, 20.8, 11.3, 11.1