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At ~1000 CE, for example, the Gulf of Mexico (GoM) and tropical North Atlantic (TNA) started a ~1 C cooling trend 5,6 that culminated in ~3 C boreal winter cooling during the Little Ice Age (LIA: 14501850 CE) 7

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J Biochem Mol Toxicol 27:451456

Appetite Effects The question about appetite is interesting because the proposed mechanism could reasonably go either direction: Reduced lipogenesis and improved metabolic flexibility could produce secondary effects on appetite regulation NAD+ restoration has complex effects on hypothalamic appetite signaling Preclinical data do not consistently describe dramatic appetite changes In human use were it to become clinically available patient-reported appetite effects would be a relevant monitoring parameter, but the data do not currently support a strong a priori expectation