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Based on the presence of AIH-2 in some 20% of APECED-syndrome patients, a transgenic model was generated by Hardtke-Wolenski et al., in which the AIRE1 gene is truncated at exon 2: 24% of these mice developed AIH-like liver damage [117]

In a second step, glutathione synthase (GshB) adds a glycine to the C-terminus of this dipeptide, resulting in -glutamyl-cysteinyl-glycine (glutathione) (Apontoweil and Berends, 1975

However, glutathione isn't absorbed well by the body so we must turn to the S-Acetyl form

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