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Not all B12 that you eat or take in supplements is absorbed and research indicates that to achieve a sufficient daily dose of B12, you should take at least five to 50 micrograms daily or 1,000 to 2,000 micrograms weekly (Del Bo et al., 2019

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Deficiency is common in those with fatigue, brain fog, or nutrient absorption issues, especially individuals with gastrointestinal conditions, vegans and vegetarians, or those taking medications like metformin or proton-pump inhibitors