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This mechanism of inhibiting proteasome activity may be achieved by targeting nuclear protein localization protein 4 homolog (NPL4), which is the adapter factor for the p97 (also known as VCP) segregase, involved in the conversion of proteins involved in multiple regulatory and stress response pathways (198)

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Zheng M, Aslund F, Storz G (1998) Activation of the OxyR transcription factor by reversible disulfide bond formation

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Figure 2 Figure 3 The patient recovered well postoperatively and has been undergoing adjuvant treatment with chemotherapy and immunotherapy