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Studies show that 5-Amino-1MQ-treated animals have visibly darker (browner) visceral fat with increased mitochondrial density and oxidative enzyme expression

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Pb 2+ also activates the synthesis and secretion of the proinflammatory cytokine IL-8 through a nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent mechanism involved in the synthesis of xenobiotic-metabolizing enzymes (Metryka et al