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2 Materials and methods 2.1 Animal model and grouping Nine-week-old male C57BL/6 mice (weighing 20 2 g at the start of the experiment) were housed under controlled conditions (22 1 C, 12 h/12 h light/dark cycle) with free access to food and water

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Cysteinyl-tRNA synthetase mutations cause a multi-system, recessive disease that includes microcephaly, developmental delay, and brittle hair and nails