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Deficiency is widespread in the UK due to limited sunlight exposure, and is particularly prevalent in those with chronic illness, darker skin tones, or conditions affecting fat absorption

Key Considerations: The neurotoxic effects of high-dose Vitamin B12 on the optic nerve

5-Amino-1MQ (5-amino-1-methylquinolinium) is a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT)

It is a major source for methyl groups via its metabolite trimethylglycine (betaine) that participates in the S-adenosylmethionine synthesis pathways

AHK-Cu has also been shown to reduce the secretion of Transforming Growth Factor-beta1 by dermal fibroblasts[2]

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