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Upon activation, free radicals such as nitric oxide (NO) and superoxide are released, which elevates oxidative stress contributing to pathogen elimination and local tissue damage ( Migraine Pathogenesis: Role of Oxidative Stress, Neuroinflammation, and Mitochondrial Dysfunction Migraine is defined as a neurovascular disorder involving cortical spreading depression (CSD), neurogenic inflammation, and dysfunction in cranial vascular contractility ( Oxidative Stress Oxidative stress role in migraine pathogenesis is emphasized by multiple studies

Minekus M, Alminger M, Alvito P, Ballance S, Bohn T, Bourlieu C, Carrire F, Boutrou R, Corredig M, Dupont D, Dufour C, Egger L, Golding M, Karakaya S, Kirkhus B, Le Feunteun S, Lesmes U, MacIerzanka A, MacKie A et al (2014) A standardised static in vitro digestion method suitable for food-an international consensus

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Recent studies suggest that BPC-157 may accelerate nerve regeneration and relieve neuroinflammation

doi: 10.3389/fimmu.2022.946628 55 GuziorD

Houben K, Dominguez C, van Schaik FM, Timmers HT, Bonvin AM, Boelens R