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Notably, a single intravenous administration (0.5 mg/kg) of -Gal A mRNA into Fabry mice achieved long-lasting (at least 12 weeks) attenuation of Gb3 accumulation in tissues, suggesting that less frequent dosing of mRNA therapy may be required compared to the conventional ERT therapy, which is administered biweekly [180]

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Topical GHK-Cu dosage is consequently expressed as a percentage concentration rather than an absolute mass

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Evaluation of vitamin B12 monitoring in a veteran population on long-term, high-dose metformin therapy