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MicroRNAs and Autoimmune-Mediated Eye Diseases

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Kim 16 , Andres Duarte-Rojo 17 , Omobonike Oloruntoba 18 , Amit D

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2.6 P53 The p53 protein serves a critical role in the cellular response to iron overload, maintaining a balanced state of iron by finely regulating the transcriptional activity of specific genes ( Moreover, p53 is not only involved in iron homeostasis regulation but also enhances the cellular antioxidant defense system by activating the expression of a series of antioxidant enzymes, including GSTs, HO-1, and superoxide dismutase (SOD) ( When the skin is exposed to harmful environmental factors, such as ultraviolet rays, the p53 protein promptly activates its protective mechanism ( Moreover, p53 plays a pivotal role in combating skin aging

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doi: 10.1002/mds.22875 159

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The wrapping loop is an extended region of almost 110 residues that link the -barrel and -helical parts

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Verhaart IEC, Robertson A, Wilson IJ, Aartsma-Rus A, Cameron S, Jones CC, Cook SF, Lochmller H (2017) Prevalence, incidence and carrier frequency of 5q-linked spinal muscular atrophyA literature review

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