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Moreover, mGluR5 is activated to inhibit LDH activity, thereby increasing the Bax/Bcl-2 ratio [37]

Furthermore, the complete absence of experimental data from cellular or animal models precludes determination of causal roles versus epiphenomena

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Future directions Further molecular imaging studies in LLD are critically needed to understand the neurobiological differences in trajectories of LLD, as indicated by the gaps in the literature identified

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