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However, more rigorous research, including randomized clinical trials, is still needed to fully understand the effectiveness and long-term efficacy of e-cigarettes as a smoking cessation tool

Park J, Kim I, Oh YJ, Lee K, Han PL, Choi EJ: Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2

This instability may result from inadequate demethylation of conserved non-coding sequence regions in the Foxp3 locus, known as the Treg-specific demethylation region (TSDR), which is fully demethylated in thymus-derived Tregs (tTregs) but often methylated in iTregs (38)