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After host cell entry, the ORF9b of SARS-CoV-2 RNA could directly manipulate mitochondrial function to evade host cell immunity, facilitate viral replication and trigger the onset of COVID-19

Note: no metabolites return to glycolysis in this case

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CAF-secreted Gln is taken by tumor cells that highly express the Gln transporters SLC1A5 and SCL38A2 and is utilized to maintain tumor growth [124]

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