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Although FASN inhibition can result in the accumulation of malonyl-CoA, a metabolic flux analysis using ethyl acetate-2- 13 C revealed that the direct elongation of LA (C18:2) to AA (C20:4) was not facilitated, suggesting that AA may be imported from the microenvironment 60

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ACS Nano 11 (4), 39733983

Furthermore, NCs exert cell cycle arrest, either at the G0/G1 or G2/M phase, while also inhibiting the genes for proliferation and suppressing oncogenic signalling pathways such as PI3K/Akt, MAPK, JAK/STAT3, NF-B, mTOR, and Wnt/-catenin