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10.1126/science.aac9462 54 JonasP.BurnashevN

There is considerable uncertainty about the relevance of vitamin B12 supplementation for neurological function in older people in the absence of anaemia or macrocytosis

Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin

Mitochondrial-mediated apoptotic pathways are activated in both malignant clones and sensitive normal compartments (e.g., intestinal crypt stem cells, granulocyte-macrophage progenitors), driving dose-limiting gastrointestinal and myelosuppressive toxicities ( 3.2 Death receptor-induced apoptosis as a promising anticancer modality Genetic studies indicate that apoptosis triggered by TNFR family death receptors is pivotal in conferring resistance to chemotherapeutic agents (Sartore-Bianchi et al., 2016)