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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

Start with 200mcg daily of selenomethionine, never exceed 400mcg per day, and trial it for 4-8 weeks

2002 May;58(5):422-8

This bidirectional regulatory process involves multiple interrelated mechanisms, including dysregulation of local prolactin synthesis and secretion (e.g., originating from adipose tissue or other extrapituitary tissues), alterations in prolactin metabolism and clearance processes, and a persistent chronic low-grade inflammatory state ( Figure 2 )

10.3390/ph18091360 12 BertonO.NestlerE

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