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Mashiach 2001

Josifovska S

Dialysis-related carnitine disorder and levocarnitine pharmacology

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5 There are many theories as to why excess ammonia causes encephalopathy

Key limitations of the existing evidence include: Small sample sizes in many studies Heterogeneous patient populations Variable dosing regimens (typically 35 grams daily) Short follow-up periods (often 4-12 weeks) Inconsistent outcome measures Potential publication bias favouring positive results Some studies have investigated combination approaches