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In contrast, Y37HYP mutation significantly increased rat amylin(2737) affinity for amylin receptor 3 ECD by 3-fold compared to Y37P mutation (Figure 6C and Table 2)

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While spine density provides an approximate estimate of the total number of excitatory synapses onto the postsynaptic neuron, the location of a spine influences the contribution of its synaptically transmitted electrical and chemical signals to the integrated response at the soma ( SPINE DYNAMICS DURING DEVELOPMENT Spine density varies significantly across diverse populations of neurons, likely reflecting the diversity of neuronal morphology and function ( Figure 1 )

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The poor permeability and the function of the BBB arise from its structure: tightly packed endothelial cells, supported by astrocytes and pericytes, shield the brain from toxins and pathogens

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