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Excessive ROS can be reduced by cellular antioxidant systems, such as the Nrf2-mediated antioxidant system, GSH, and NADPH [18, 19]

Supported by patents and peer-reviewed studies from Japan in 2018 and 2020, EYEMUSE features a unique, heat-inactivated form of Lacticaseibacillus paracasei KW3110 that has been shown in human trials to help reduce screen-related eye fatigue and support comfort during prolonged use of digital devices

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Biol Res 42:315326 Sasaki-Sekimoto Y, Taki N, Obayashi T, Aono M, Matsumoto F, Sakurai N, Suzuki H, Hirai MY, Noji M, Saito K, Masuda T, Takamiya K, Shibata D, Ohta H (2005) Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis

666 Both zinc and copper contribute to the deposition and stabilization of amyloid plaques, and chelators were shown to solubilize amyloid deposits

Recent reports indicate a more complex mechanism in which wild-type p53 may enhance survival advantage by promoting antioxidation in some cases, and p53-mediated activation of p21 (encoded by CDKN1a) inhibits phospholipid oxidation by protecting intracellular mercaptans (including GSH) (Tarangelo et al., 2018