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Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats

280 Another study on BCLM showed that the quantification of ctDNA in the participants cerebrospinal fluid achieved a remarkable 100% sensitivity and specificity in diagnosing BCLM, exceeding the traditional gold standard cytology method

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Mechanistically, HPE enhanced insulin signaling by increasing the phosphorylation levels of insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and glucose transporter type 4 (GLUT4) in the liver, thereby activating the IRS1PI3KAKTGLUT4 pathway and improving insulin resistance