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Kelly E, Greene CM, Carroll TP, McElvaney NG, O'Neill SJ

These findings support the relevance of MGBA mechanisms in BD pathophysiology, implicating both immune and metabolic pathways as shown in Table 8, and are conceptually illustrated through the microbiotaimmunemetabolicbrain axis model (Figure 6

Through fermentation, Lactobacillus species generate a diverse range of metabolites

Further pharmacokinetic studies are needed to determine the effective doses of mTOR inhibitors for inducing autophagy with minimal side effects

6 , a026831 (2016)