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It plays a vital role in neutralizing free radicals, reducing oxidative stress, and supporting immune function

One of the key regulators of oxidative stress in diabetes is thioredoxin-interacting protein (TXNIP), which acts as an endogenous inhibitor of the antioxidant thioredoxin (TRX)

Preliminary evidence of efficacy in COVID-19 is available for tocilizumab through small studies

This adaptation is mediated by upregulation of the thioredoxin antioxidant system and an increase in surface thiol group density, forming a protective reducing barrier that shields NK cells from oxidative damage [176]

Sources of ROS are multiple and include known environmental risk factors for schizophrenia but also genetic factors, dopamine metabolism, antipsychotics and inflammation

On day 5 post-exposure, Nrf2-KO mice showed a transient increase in ABR thresholds, which returned to base-line by day 14