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Relevance of the glutathione system in temporal lobe epilepsy: Evidence in human and experimental models

Is it synergy or antagonism

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The association observed with GPX3 could similarly reflect changes in oxidative stress, where the decrease in GPX3 is in parallel with gains in endogenous insulin secretion and improved glycaemic control

Irving, P

GPX4 activity depends on GSH and selenium levels, which also affects either the Grx system (GSH-dependent activity of Grxs) or the Trx system (selenium-dependent activity of TrxR)