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Accordingly, we found that TFE3-S is mostly located to the cytosol under control conditions and only translocated to the nucleus following mTORC1 inactivation with Torin-1 (Fig

Combination regimens incorporating PD-1/PD-L1 inhibitors with modalities such as chemotherapy, radiotherapy, complementary immunotherapies or targeted agents have demonstrated enhanced therapeutic efficacy (181)

In contrast, adiponectin, which plays an essential role in insulin sensitivity (Reference Bagheri, Rashidlamir and Ashtary-Larky10) , is reduced, linking its role to insulin resistance and type 2 diabetes mellitus (Reference Sirico, Bianco and DAlicandro8)