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By reducing the number of LDL receptors (LDLR) on the surface of liver cells, PCSK9 leads to the accumulation of LDL-C, increasing the risk of CVDs

J Cell Physiol (2009) 221(2):4249

(New York: Oxford University Press), 187267

Even though one of the most important predictors of growth impairment is the degree of renal insufficiency, significant short stature has been seen at all levels of renal function [3, 7]