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Nat Cell Biol 20:13891399

PMID 28254655 Sikiric P, Seiwerth S, et al

We validated glutathione and -galactosidase (cell senescence) as biomarkers of ionizing radiation damage

LogP: -2.8 (highly hydrophilic)

Additionally, under CCH conditions, TNF- activation induces the downregulation of the TJ protein claudin-5, an alteration strongly correlated with the formation of deep brain white matter lesions (26)