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Absence of N-linked glycosylation of IGF-1R affects its membranous localization 46

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In general, body weight gain reduction, decrement of pulmonary function, and pathological changes in nose, upper airways, and lungs have been documented in most species exposed to concentrations of 1.6 mg/m 3 or more for 8 h/day

A combination of assays, including CSF -syn and other biochemical indicators, MRI imaging markers, SPECT or PET imaging, non-motor symptoms, and cognitive function scores, should be utilized to detect early PD because individual biomarkers are difficult to diagnose reliably

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