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Dose and route selection of GEN, NaS, and CCM In the current study, GEN was intraperitoneally injected at 120 mg/kg bwt This dose has been chosen based on several earlier studies that confirmed the GEN ototoxic effect at this dose, route, and duration of exposure (Sagit et al

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Thus, their abnormal expression can halt the normal immune response, leading to autoimmunity

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ROS and angiogenesis Elevated ROS levels (particularly NOX4-induced H 2 O 2 ) promote angiogenesis through redox-mediated pathways, with HIF1 playing a central role by directly upregulating VEGF and angiogenic factors like angiopoietin-2 and endothelin-1 (EDN1), particularly in colon cancer

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