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The Diagnosis and Management of Thyroid Nodules: A Review [published correction appears in JAMA

However, research shows that people with low B12 tend to have higher BMI, reduced physical activity, disrupted fat cell gene expression, and elevated homocysteine, all of which can contribute to gradual weight gain over time

Typically, however, treatment for hypothyroidism starts with T4-only formulations, based on the assumption that the body will successfully convert T4 into T3 on its own