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for instance, IL-1 activates the Mitogen-Activated Protein Kinase (MAPK) pathway to enhance serotonin transporter (SERT) activity, leading to decreased synaptic 5-HT concentrations and thereby further inducing depressive-like behaviors (Zhu et al., 2010)

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doi: 10.1002/ajmg.10100

Reduced peptide sample was added to top of the stage-tip and then centrifuged at 500 g for 2 min

The aged HG cells can also be reactivated to regenerate upon the activation of mitophagy or GSH metabolism

Schematic of key metabolites and enzymes (red) downstream of SAM