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Kerr et al, 2012), where the cisplatin (CDDP) insult is delivered to prepubertal mice which have a high primordial follicle reserve

After TBI, there is an activation of neuroinflammation response pathway mediated by microglia cells that were not initially damaged, and the activated microglial cells may promote the release of proinflammatory factors such as interleukin 1, tumor necrosis factor, nitric oxide, etc., (Kumar and Loane, 2012), inducing a progressive cycle of chronic inflammation (Sulhan et al., 2020)

There are two main sets of GWI case definitions (5)

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