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Several factors cause this: Lower stomach acid production [6] Less intrinsic factor [6] Interference from medications (especially proton pump inhibitors and metformin) [6] Atrophic gastritis affects 8-9% of adults over 65, which makes nutrient absorption even harder [7]

Patients who can tolerate gastrointestinal side effects during the initial titration period typically achieve substantial long-term weight loss

Decreased Inflammation : Adipose tissue (body fat) produces inflammatory cytokines that contribute to systemic inflammation

Reduced Fatigue and Increased Motivation : Many individuals on weight loss or fitness journeys struggle with fatigue, which can hinder progress

Patients starting semaglutide are often already on metformin or proton pump inhibitors (which block tablet absorption)

However, for numerous seniors, these symptoms can indicate a deficiency in vitamin B12