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1e, f) suggested placement of polar and non-polar substituents in multiple locations, including those that were relatively remote, we intentionally limited the modifications to those in proximity or to the putative chimera molecule itself to maximize the potential for further improvements during structure-activity relationship (SAR) studies

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While the use of these animal models has led to a wealth of discoveries, the translation of this knowledge into clinical applications has yielded inconsistent results (Kirkeby et al., 2025