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10.1038/s41419-025-07510-6 17 DixonS

Flare management Fibromyalgia typically involves symptom flares

3 Targeting ferroptosis anti-osteoporosis drugs The primary features of ferroptosis include an excess of iron and the buildup of ROS, with lipid peroxidation being its key mechanism ( 3.1 Regulation of iron metabolism Iron chelators demonstrate significant clinical efficacy in patients with osteoporosis resulting from iron overload, primarily by reducing intracellular free iron levels

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For example, Steinhoff and his colleagues investigated the association of GSTT1 null genotype with both bladder and prostate cancer risk[9]

Once glutamate is taken by astrocytes, it can be converted to glutamine in an energy-dependent manner via the glial-specific enzyme, glutamine synthetase (GS