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Vitamin A is a fat-soluble vitamin essential for immune function, vision, and hepatic metabolism

Taken together, Lambert and colleagues concluded that acrolein and other 2-alkenals found in cigarette smoke can disrupt physiological regulation of gene expression by direct modification of the DNA-binding domain of a transcription factor and, as a consequence, they may cause immunosuppression upon exposure via cigarette smoke

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Moreover, in the presence of H2O2, metHb can perform a peroxidative reaction (i.e., it exhibits pseudoperoxidase activity), resulting in the formation of oxoferrylHb, a strong oxidant with the iron in the ferryl state Fe(IV) (54)

By activating AREs, NRF2 enhances the transcription of genes that encode for antioxidant proteins and enzymes, such as GPX4, which reduces lipid peroxides and mitigates oxidative stress

Higher levels of melanin result in darker skin tones