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Additionally, adherence to treatment after 1 year of smoking cessation was significantly higher amongst participants using e-cigarettes (80%) compared to those using nicotine replacement therapy (9%)

Trabectedin was the first marine-derived antineoplastic drug approved in 2007 for the treatment of patients with advanced STS after the failure of doxorubicin [9,10,11]

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However, these measures are susceptible to interpretive bias and fail to accurately capture dynamic fatigue states, which may undermine data reliability [186, 187]

doi: 10.1182/blood-2008-03-146720 110 RiksenNPNeteaMG

The mixes were incubated for 15 min at room temperature and supplemented with 0.2 M E1 UBA1 and 20 M ubiquitin to initiate the reaction