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discovered the transcription factor HIF associated with hypoxic stress under low-oxygen conditions ( Figure 1 )

7 , eabf4130 (2021)

56 PNPLA3 I148M variant has limited hydrolase activity, therefore halts retinyl ester release, and finally accumulating of TGs and retinyl esters in the hepatocytes and stellate cells, leading to fatty liver

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