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Predicting survival rate by plasma biomarkers and clinical variables in syndromes associated with frontotemporal lobar degeneration

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But after treatment, levels of ALT and AST in both groups decreased obviously, and the treatment group displayed significantly lower levels of ALT and AST than the control group ( P = .017, P = .014) ([31.09 11.95] vs [44.26 30.88], and [69.22 30.76] vs [93.74 51.88])

Meng, Q., Wei, K

Further supporting the role of LA as a zonulin inhibitor, one study found that LA treatment reduced both rearrangement and redistribution of actin and the tight junction-associated protein zonula occludens-1 (ZO-1) in Caco-2 brush-border-expressing cells that were exposed to AT-1002, a synthetic hexamer peptide derived from the active Zot fragment that has been shown to increase tight junction permeability (24)