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3.1.3.1 Cardiac function and cardiac nerve damage LPS, a key component of Gram-negative bacterial cell walls, induces cardiac dysfunction by disrupting myocardial electrical activity and neural regulation, with the magnitude of its effects modulated by baseline disease status, sex differences, and individual adaptive responses

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Gpx8 knockout in mice severely exacerbated DSS-colitis and reduced gut microbiome diversity ( Gpx8 / mice post-DSS treatment expressed higher levels of pro-inflammtory cytokines (IL-1 and IL-6) and adoptive transfer of Gpx8 -deficient macrophages into mice prior to DSS treatment resulted in an exacerbated colitis phenotype indicating a protective role for GPx8 in macrophages during experimental colitis ( Gpx8 / mice was found to be dependent on its action on caspase-11