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Interestingly, surviving mature OLGs produce fewer new myelin sheaths than newly formed OLGs, but they better preserve the pattern of myelination in the cortex, with potential implications for functional recovery (Bacmeister et al., What Curbs Spontaneous Myelin Repair

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A large scale high-throughput screening of compounds with remyelinating effects identified a cluster of anti-muscarinic formulations, including clemastine, that enhance OPC differentiation and remyelination in vitro 43

Ying et al., 2024)

19 has also reported dendrite disruption in hippocampal CA1 region and behavioral disorders in neuron-specific GCL knockdown mouse

3.2.1 Background BD is a chronic psychiatric condition characterized by alternating episodes of depression and elevated mood states, which may manifest as mania or hypomania