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In addition to cytoskeletal dynamics influencing FBP production via aldolase regulation, another trigger for increased glycolysis might be an elevated glucose uptake during cell migration 60

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Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

Lymphatic targeting may be achieved via the delivery of macromolecular therapeutics (for example, proteins and peptides), small-molecule therapeutics in association with macromolecular carriers (for example, nanoparticles, polymers, liposomes and dendrimers) or small-molecule therapeutics that associate, in situ , with endogenous macromolecular constructs (for example, lipoproteins and proteins) or cells that are transported from interstitial tissues via lymphatic rather than blood capillaries

Unlike Phase 1, which relies primarily on enzyme activity, Phase 2 conjugation requires an adequate and ongoing supply of specific substrates to safely neutralize activated metabolites