melenic versus melanotic stool What Does It Mean If My Poop Is Black? Melena Guide Melena: What Is It, Causes,

Hu C, Liu JY, Wang W, Mota-Sanchez D, He S, Shi Y

Many people maintain adequate B12 levels throughout their semaglutide treatment, especially those who start with robust B12 stores, eat a varied diet including animal products, and are not taking other B12-depleting medications

Retrieved 24 April 2021

How Peptides May Affect Insulin Sensitivity Scientists are studying how peptides affect metabolic pathways

What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology

Bendl, J