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These results suggest improvement in insulin sensitivity, and moreover, no additional side effects to those found with placebo were observed in T1D, meanwhile in T2D patients oedema, jaw pain and arthralgias were 4 % lower than previous reports [276, 277]

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Current platforms can only mediate single-base C-to-T or A-to-G conversions, leaving the majority of pathogenic variants unaddressed and offering no capacity for insertions, deletions, or larger-scale genomic modifications [555, 556]

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Basic Clin Pharmacol Toxicol 103:414418