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In relapsed or refractory myeloma (R/R MM) patients, the CD38 expression levels are relatively high in NK cells, regulatory B cells (Bregs), Tregs and myeloid-derived suppressor cells (MDSCs) compared with CD8 + and CD4 + T cells, indicating that CD38 is involved in providing the immunosuppressive environment for tumor growth [19]

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Given that SORLA inhibits amyloidogenic processing of APP [8], we next investigated whether the increased SORLA levels observed in the brains of auranofin-treated mice would result in reduced BACE1-mediated cleavage of APP and decreased A generation

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