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A 2021 review confirmed no clinical trials targeting NNMT had been reported [5], and MOTS-c likewise has no large human efficacy trial proving it works as a fat-loss therapy

NPJ Vaccines 9 , 235 (2024)

New opportunities for RGD-engineered metal nanoparticles in cancer

Studies consistently show that participants in placebo arms of weight loss trials lose 2-5% of their body weight simply from the behavioral changes that come with enrolling in a treatment program, including dietary awareness, increased motivation, and regular check-ins with healthcare providers