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Eugenol significantly alleviates the downregulation of GPX4 and antioxidant Nrf2 in diabetic-induced pancreatic tissues, protecting -cell viability and function by inhibiting ferroptosis [91]

As a result, NOX2 silencing significantly reduced the number and size of HCC in mouse HCC model

Research has demonstrated that timing glucocorticoid therapy to coincide with the nocturnal increase in inflammatory markers can lead to substantial improvements in patient outcomes, significantly reducing morning stiffness and pain compared to administering the same dose at other times of the day (Levi et al., 1985

Howe GR, et al

The third stage is clinical qualification, where the biomarkers correlation with disease outcomes, its added prognostic value, and its consistent performance are verified in larger, independent patient cohorts